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Natural Immune Support & Health Benefits Explained

Indigo wood, Chinese indigo, Woad root

What is Isatis Root?

Isatis root is a powerful herb traditionally used in both Traditional Chinese Medicine (TCM) and Ayurveda. Known for its detoxifying and immune-boosting properties, Isatis root has been used for centuries to support respiratory health and reduce inflammation. Derived from the same plant used to make indigo dye, it is widely used in Asia to boost the immune system [1][2].

Potential Uses and Benefits of Isatis Root

  • 1. To Treat Bronchitis and Relieve Chest Congestion

    Isatis root has been shown in laboratory studies to exhibit anti-inflammatory properties, which may help alleviate respiratory conditions like bronchitis. The herb continues to be used traditionally in Asia to support respiratory health [13][14].

  • 2. To Support Immune Health and Fight Infections

    Research on Isatis root has shown that it contains active compounds with antiviral and immune-stimulating effects. This has made it a popular choice for immune support, especially during cold and flu season [8][11]. Studies suggest that Isatis root may help reduce the severity of viral infections, including the flu [5][19].

  • 3. Potential Role in COVID-19 Support

    Isatis root played a crucial role during the COVID-19 pandemic. Research using network pharmacology has shown that the active compounds in Isatis root may interact with several biological processes involved in viral infections, such as the interleukin-17 signaling pathway, tumor necrosis factor pathway, and p53 signaling pathway [4][22].

  • 4. Cancer Support

    Preliminary studies have shown that Isatis root contains compounds like indirubin, which may inhibit cancer cell growth by stopping cell duplication [3][12]. In TCM, Isatis root is sometimes used in combination with other herbs to support cancer treatment [3].

  • 5. Traditional Use for Cold and Fever

    Traditionally, Isatis root has been used to relieve symptoms of colds, fevers, and flu-like illnesses. Laboratory research has confirmed its antiviral properties. During flu season, Isatis root remains a popular supplement in Asia [1][2][8].

Side Effects and Safety

Oral Use

No major side effects have been reported with the oral use of Isatis root [7]. However, it's important to consult with your healthcare provider before using any herbal supplement, especially if you are taking other medications.

What Else Should You Know?

Patient Safety

If you're taking Isatis root or any other supplements, inform your healthcare provider. This helps manage potential interactions with other medications, particularly those that may be metabolized by enzymes affected by Isatis root compounds [24].

Interaction with Drugs

Studies suggest that Isatis root compounds, such as indirubin, may influence how certain medications are metabolized, particularly those processed by CYP450 3A4 enzymes. Though clinical relevance is still unclear, consult with your doctor if you're on such medications [24].

Ongoing Research and Emerging Insights

While these potential uses are supported by laboratory and preliminary studies, more human research is necessary to confirm the full extent of Isatis root's benefits. The findings from traditional uses and early-stage studies are promising, but it is important to acknowledge that clinical trials in humans are still limited

Disclaimer

This information is for educational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare provider before starting any new supplement, especially if you are pregnant, nursing, or taking medications.

References

1.Zou P, Koh HL. Determination of indican, isatin, indirubin and indigotin in Isatis indigotica by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(7):1239-1246.

2.Bensky D, Gamble A. Chinese Herbal Medicine: Materia Medica Revised ed. Seattle, WA: Eastland Press; 1993.

3.Hoessel R, Leclerc S, Endicott JA, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. May 1999;1(1):60-67.

4.Lin CW, Tsai FJ, Tsai CH, et al. Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res. Oct 2005;68(1):36-42.

5.Yang Z, Wang Y, Zheng Z, et al. Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro. Int J Mol Med. Apr 2013;31(4):867-873.

6.Wu Y, Zhang ZX, Hu H, et al. Novel indole C-glycosides from Isatis indigotica and their potential cytotoxic activity. Fitoterapia. Mar 2011;82(2):288-292.

7.Qi CX, Wu XM, Wang XL. [Clinical research of isatis root eyedrops on the acute bacterial conjunctivitis]. Zhong Yao Cai. Jan 2007;30(1):120-122.

8.vitro of tetraploid Isatis indigotica]. Zhongguo Zhong Yao Za Zhi. Jun 2000;25(6):327-329.Wang Y, Qiao CZ, Liu S, et al. [Evaluation on antiendotoxic action and antiviral action in

9.Hsuan SL, Chang SC, Wang SY, et al. The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus. J Ethnopharmacol. May 4 2009;123(1):61-67.

10.Li J, Liu Y, Fang J, et al. Effect of Radix Isatidis on the expression of moesin mRNA induced by LPS in the tissues of mice. J Huazhong Univ Sci Technolog Med Sci. Apr 2007;27(2):135-137.

11.Xu YM, Lu PC. [Experimental studies on immunostimulatory effects of the Isatis indigotica polysaccharide]. Zhong Xi Yi Jie He Za Zhi. Jun 1991;11(6):357-359, 325-356.

12.Chung YC, Tang FY, Liao JW, et al. Isatis indigotica induces hepatocellular cancer cell death via caspase-independent apoptosis-inducing factor translocation apoptotic pathway in vitro and in vivo. Integr Cancer Ther. Jun 2011;10(2):201-214.

13.You WC, Lin WC, Huang JT, et al. Indigowood root extract protects hematopoietic cells, reduces tissue damage and modulates inflammatory cytokines after total-body irradiation: does Indirubin play a role in radioprotection? Phytomedicine. Dec 2009;16(12):1105-1111.

14.Ho YL, Chang YS. Studies on the antinociceptive, anti-inflammatory and anti pyretic effects of Isatis indigotica root. Phytomedicine. Jul 2002;9(5):419-424.

15.You WC, Hsieh CC, Huang JT. Effect of extracts from indigowood root (Isatis indigotica Fort.) on immune responses in radiation-induced mucositis. J Altern Complement Med. Jul 2009;15(7):771-778.

16.Chen J, Dong X, Li Q, et al. Biosynthesis of the active compounds of Isatis indigotica based on transcriptome sequencing and metabolites profiling. BMC Genomics. 2013;14:857.

17.Zhang CE, Xiong Y, Dong Q, et al. Comparison of reversed-phase liquid chromatography and hydrophilic interaction chromatography for the fingerprint analysis of Radix Isatidis. J Sep Sci. 2014 May;37(9-10):1141-7.

18.Shi YH, Xie ZY, Wang R, et al. Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Isatis indigotica based on Ultra-Performance Liquid Chromatography with Photodiode Array Detector Combined with Chemometric Methods. Int J Mol Sci. 2012;13(7):9035-9050.

19.Yang Z, Wang Y, Zhong S, et al. In vitro inhibition of influenza virus infection by a crude extract from Isatis indigotica root resulting in the prevention of viral attachment. Mol Med Rep. Mar 2012;5(3):793-799.

20.Molina P, Tarraga A, Gonzalez-Tejero A, et al. Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. J Nat Prod. Oct 2001;64(10):1297-1300.

21.Centers for Disease Control and Prevention. Public Health Guidance for Community-Level Preparedness and Response to Severe Acute Respiratory Syndrome (SARS) Version 2/3. 2014. Accessed May 4, 2022.

22.Li Z, Li L, Zhou H, et al. Radix isatidis Polysaccharides Inhibit Influenza a Virus and Influenza A Virus-Induced Inflammation via Suppression of Host TLR3 Signaling In Vitro. Molecules. Jan 11 2017;22(1).

23.Xu H, He L, Chen J, et al. Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to testify the theory of superposition of traditional Chinese Medicine efficacy. J Ethnopharmacol. Jul 15 2019;239:111901.

24.Kumagai T, Aratsu Y, Sugawara R, et al. Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor. Drug Metab Pharmacokinet. Apr 2016;31(2):139-145.

25.Wu L, Chen Y, Ma Y, et al. Clinical practice guideline on treating influenza in adult patients with Chinese patent medicines. Pharmacol Res. Oct 2020;160:105101.